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Juicer66
08-14-2021, 10:27 AM
SUBJECT :- Antibody Dependency Enhancement
Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination .



Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain.
Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants.
Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains.
This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain.
However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.
Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).

Antibody Dependent Enhancement (ADE) is every virologists worst nightmare. It means the vaccine does the opposite of what was intended.
“In antibody-dependent enhancement, sub-optimal antibodies bind to both viruses and gamma receptors expressed on immune cells, then promoting infection of these cells.” In other words, your immune cells themselves BECOME infected and carry the virus.
Vaccinated antibodies will be a trojan horse that gives the virus entry into cells. ALL CELLS. The whole human body.
We will see massive sickness and death within the vaccinated. Boosters will likely make the situation even worse.
Quote: “ Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).”

Translation: The shot makes a subsequent Infection “strikingly” worse (their words) and everybody was vaxxed using the original strain.
By the way, given that ADE from MRNA in animal trials killed all of them, the word “concern” is a euphemism for “fucking scared.”

Quote: “ the possibility of ADE should be further investigated as it may represent a potential risk for mass vaccination during the current Delta variant pandemic.”
Further investigated. Yeah right… when? By whom?
The same Quacks that gave us all this trouble in the first place?

Quote: “ Since the Covid-19 pandemic is now dominated with Delta variants.”
So … this is a “concern” for anyone taking the first shot (actually everyone) as mass vax is a risk for the Delta variant which is now the dominant variety.


The world now has the worst case scenario. We have it BECAUSE of the vaccine.


Doctor ( Genius )Judy Mikovits among others told you all this right from the start . I have continuously parroted it because of its scientific base . If you could not bother to find out yourself ----------



SOURCE The “Journal of Infection” is a monthly peer-reviewed medical journal in the field of infectious disease, covering microbiology, epidemiology and clinical practice. Established in 1979, the journal was initially published quarterly by Academic Press.
The Journal is the cutting-edge of information for Doctors specializing in Infectious Diseases. It is considered a “must read” each month by Infectious Disease Specialists.
On August 9, The Journal of Infection published this peer-reviewed study

revelarts
08-29-2021, 09:10 AM
just adding Links

https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351274/

https://pubmed.ncbi.nlm.nih.gov/34384810/

Tyr-Ziu Saxnot
08-29-2021, 01:19 PM
SUBJECT :- Antibody Dependency Enhancement
Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination .



Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain.
Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants.
Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains.
This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain.
However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.
Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).

Antibody Dependent Enhancement (ADE) is every virologists worst nightmare. It means the vaccine does the opposite of what was intended.
“In antibody-dependent enhancement, sub-optimal antibodies bind to both viruses and gamma receptors expressed on immune cells, then promoting infection of these cells.” In other words, your immune cells themselves BECOME infected and carry the virus.
Vaccinated antibodies will be a trojan horse that gives the virus entry into cells. ALL CELLS. The whole human body.
We will see massive sickness and death within the vaccinated. Boosters will likely make the situation even worse.
Quote: “ Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).”

Translation: The shot makes a subsequent Infection “strikingly” worse (their words) and everybody was vaxxed using the original strain.
By the way, given that ADE from MRNA in animal trials killed all of them, the word “concern” is a euphemism for “fucking scared.”

Quote: “ the possibility of ADE should be further investigated as it may represent a potential risk for mass vaccination during the current Delta variant pandemic.”
Further investigated. Yeah right… when? By whom?
The same Quacks that gave us all this trouble in the first place?

Quote: “ Since the Covid-19 pandemic is now dominated with Delta variants.”
So … this is a “concern” for anyone taking the first shot (actually everyone) as mass vax is a risk for the Delta variant which is now the dominant variety.


The world now has the worst case scenario. We have it BECAUSE of the vaccine.


Doctor ( Genius )Judy Mikovits among others told you all this right from the start . I have continuously parroted it because of its scientific base . If you could not bother to find out yourself ----------



SOURCE The “Journal of Infection” is a monthly peer-reviewed medical journal in the field of infectious disease, covering microbiology, epidemiology and clinical practice. Established in 1979, the journal was initially published quarterly by Academic Press.
The Journal is the cutting-edge of information for Doctors specializing in Infectious Diseases. It is considered a “must read” each month by Infectious Disease Specialists.
On August 9, The Journal of Infection published this peer-reviewed study

If this --proves--to be in the worst case scenario-- the number of dying will in the end be worse than that of the bubonic plague(called the black death).
And that came about through Nature --while this if it pans out as described will be by way of mankind and its usual darkness, greed and lust for power..
The entire had better pray that this is not so..-Tyr

jimnyc
08-29-2021, 01:24 PM
There is no evidence to suggest COVID-19 vaccines will kill people by causing antibody- dependent enhancement, current evidence demonstrates the opposite

A baseless quote has been widely attributed to a Nobel Prize winner to claim people will die from antibody-dependent enhancement after receiving a COVID-19 jab. There is no evidence to back up this claim, nor was Reuters able to find any instance where the laureate made this comment.

The claim, made in a post that has been screenshot and shared on social media platforms, says French virologist Luc Montagnier “has confirmed that there is no chance of survival for people who have received any form of the vaccine”. (here , here and here).

It then quotes him as saying: “’There is no hope, and no possible treatment for those who have been vaccinated already. We must be prepared to incinerate the bodies.’” The post adds: “The scientific genius backed claims of other pre eminent [sic] virologists after studying the constituents of the vaccine. ‘They will all die from antibody dependent enhancement.’ Nothing more can be said.’”

Montagnier won the Nobel Prize for medicine in 2008 with fellow scientist Francoise Barre-Sinoussi for their work identifying the HIV virus (here). More recently, Montagnier has been criticised for comments regarding HIV and the immune system, as well as a claim that SARS-CoV-2, the virus that causes COVID-19, was leaked from a laboratory (bit.ly/3bUQZnT). These comments are outside the scope of this check.

Reuters was unable to find any evidence that Montagnier made the comments quoted in the social media posts. Links included in the post also offered no extra evidence: one was a Wikipedia page for the scientist and a second was for a video interview in which Montagnier talks about variants and vaccines (here).

The 2-minute interview clip shows Montagnier claiming COVID-19 vaccines cause antibody dependent enhancement (ADE) – in other words, they cause worse disease than before. He says this is apparent by observing where “the curve of vaccination is followed by the curve of deaths”.

However, this is not accurate. While ADE was a concern initially contemplated by scientists creating COVID-19 vaccines (here), there have been no signs of cases happening during clinical trials or the roll-out (here , here and here).

Moreover, COVID-19 vaccines have been shown to save thousands of lives. England alone has estimated the vaccines have averted more than 10,000 deaths up to the end of March 2021 (here). Similar results have also been observed in Israel, which has led one of the fastest vaccination campaigns in the world (here).

“Overwhelmingly, vaccinated people are showing protection against severe COVID-19 cases and hospitalisations,” said medical experts at Meedan Health Desk when presented with Montagnier’s claim. “This would likely not happen if ADE were occurring, because it is an acute and very serious condition that would cause significant medical alarm.”

https://www.reuters.com/article/factcheck-health-coronavirus/fact-check-there-is-no-evidence-to-suggest-covid-19-vaccines-will-kill-people-by-causing-antibody-dependent-enhancement-current-evidence-demonstrates-the-opposite-idUSL2N2ND0WS

jimnyc
08-29-2021, 01:28 PM
As far Judy Mikovits, I would simply advise anyone to do some background reading and make your own decisions. If you're into conspiracy stuff from your doctor, she's the one for you.

No doubt she knows a ton and is extremely intelligent. I won't debate any of that. Like I said, just read and read some more. I'm not going to tell anyone what or what not to believe on this one.

And she's even published on many a government publications and medical publications for sure - for all the wrong reasons.

Juicer66
08-29-2021, 01:59 PM
As far Judy Mikovits, I would simply advise anyone to do some background reading and make your own decisions. If you're into conspiracy stuff from your doctor, she's the one for you.

No doubt she knows a ton and is extremely intelligent. I won't debate any of that. Like I said, just read and read some more. I'm not going to tell anyone what or what not to believe on this one.

And she's even published on many a government publications and medical publications for sure - for all the wrong reasons.


Appreciate your diplomatic wording and approach .

So how about indicating one area of controversy and any key points of support for the dissent .
I genuinely know of no disagreement that stands up to any sane review and discussion but believe me I will always change my mind if persuasive contra research results emerge .

I am inclined to think that her work with colleagues to isolate XMRV retroviruses , for example , will win her a Nobel prize even if posthumous .It's implications are monumental and without Fauci et al millions would have been saved from death just from Cancer and Leukaemia .

However , in the context of this Sars2 Covid virus topic we need only be concerned with ADE , which as far as I know is an undisputed fact .And in all known past Corona virus vaccine testing has been the one thing that led to thew death of all test animals .

There has never been any human testing . That anybody has dared to admit to !

jimnyc
08-29-2021, 02:21 PM
Simply plug in her name into Google - the first page is enough, and has sources that show other professionals thinking she is wrong, to put it nicely.

https://www.liebertpub.com/doi/10.1089/AID.2020.0095
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398426/
https://www.reuters.com/article/uk-factcheck-mikovits-vaccine-50/fact-check-unfounded-claim-that-50-million-americans-would-die-from-covid-19-vaccine-idUSKBN23U2FL
https://www.rollingstone.com/culture/culture-news/plandemic-judy-mikovits-plague-of-corruption-998224/
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/86461
https://retractionwatch.com/category/by-author/judy-mikovits/
https://www.npr.org/2020/05/08/852451652/seen-plandemic-we-take-a-close-look-at-the-viral-conspiracy-video-s-claims

Believe her tripe if you will, she has been wrong MANY times before. If one still believes all she has to say, I'm cool with that. I see red flag after red flag and proven being wrong over and over.

Tyr-Ziu Saxnot
08-29-2021, 08:27 PM
Simply plug in her name into Google - the first page is enough, and has sources that show other professionals thinking she is wrong, to put it nicely.

https://www.liebertpub.com/doi/10.1089/AID.2020.0095
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398426/
https://www.reuters.com/article/uk-factcheck-mikovits-vaccine-50/fact-check-unfounded-claim-that-50-million-americans-would-die-from-covid-19-vaccine-idUSKBN23U2FL
https://www.rollingstone.com/culture/culture-news/plandemic-judy-mikovits-plague-of-corruption-998224/
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/86461
https://retractionwatch.com/category/by-author/judy-mikovits/
https://www.npr.org/2020/05/08/852451652/seen-plandemic-we-take-a-close-look-at-the-viral-conspiracy-video-s-claims

Believe her tripe if you will, she has been wrong MANY times before. If one still believes all she has to say, I'm cool with that. I see red flag after red flag and proven being wrong over and over.

Seeking more information is always a good path to take.
Sad truth is there are so damn many-- paid experts -- that say exactly what they are---paid---- to say.....
And Joe public has to decide which side to believe..
Some of us err on the side of caution and from past history know it is always a safe bet that--government is lying!
Even a safer bet when it is government that is pushing hard for something.
Especially if that -- ""something"" vastly increases their scope and powers... just sayin'

grain of salt and a very hearty skepticism seems to be a great path to follow to me...--Tyr

Black Diamond
08-29-2021, 08:33 PM
As far Judy Mikovits, I would simply advise anyone to do some background reading and make your own decisions. If you're into conspiracy stuff from your doctor, she's the one for you.

No doubt she knows a ton and is extremely intelligent. I won't debate any of that. Like I said, just read and read some more. I'm not going to tell anyone what or what not to believe on this one.

And she's even published on many a government publications and medical publications for sure - for all the wrong reasons.

She got fired for stealing a file(s) and she also conducted an experiment without it being double-blind, which corrupts the experiment.

Black Diamond
08-29-2021, 08:37 PM
Seeking more information is always a good path to take.
Sad truth is there are so damn many-- paid experts -- that say exactly what they are---paid---- to say.....
And Joe public has to decide which side to believe..
Some of us err on the side of caution and from past history know it is always a safe bet that--government is lying!
Even a safer bet when it is government that is pushing hard for something.
Especially if that -- ""something"" vastly increases their scope and powers... just sayin'

grain of salt and a very hearty skepticism seems to be a great path to follow to me...--Tyr

Skepticism is good especially after fauci proved not to be so wonderful. And I get tired of the virtue signaling all over social media. Wife and I have our own set of concerns about the vaccine without following judy and this... What's her name.. TenPenny